Publications
SELECT: 2025 – 2021 | 2020 – 2016 | 2015 – 2004
2025
Mechanism of inhibition of acid-mediated transthyretin aggregation by designed peptides. Sun X, Pedretti R, Dyson HJ, Saelices L, Wright PE. J Biol Chem. 2025 Aug 13;301(10):110594.
A Shared Amyloid Architecture in Cardiac Fibrils from Three Neuropathy-Associated ATTR Variants. Fernandez-Ramirez MDC, Afrin S, An Nguyen B, Singh V, Pekala M, Singh P, Ahmed Y, Pedretti R, Lemoff A, Kluve-Beckerman B, Chhapra F, Eisenberg D, Saelices L. bioRxiv
Structural polymorphism of ex-vivo ALECT2 amyloid fibrils revealed by cryo-EM. Afrin S, Nguyen BA, Singh V, Singh P, Bassett P, Pekala M, Evers B, Lopez C, Ahmed Y, Li L, Kallem RR, Lemoff A, Argyropoulos C, Kluve-Beckerman B, Saelices L. bioRxiv
Risk for Heart Failure and Atrial Fibrillation Across the Lifespan for Carriers of the Amyloidogenic p.V142I TTR Variant. Grodin JL, Gupta A, Rison I Jr, Kozlitina J, Saelices-Gomez L, Girotra S, Shah AM, Roth LR, Griffin JM, Drazner MH, Tang WHW, Maurer MS, de Lemos JA. Circ Genom Precis Med. 2025 Aug;18(4):e004911.
Structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations, revealed by cryo-EM. Nguyen B, Del Carmen Fernandez-Ramirez M, Bassett P, Singh V, Singh P, Pękała M, Villalon L, Ahmed Y, Lemoff A, Evers B, Lopez C, Kluve-Beckerman B, Saelices L. bioRxiv
Biomarkers in Subclinical Transthyretin Cardiac Amyloidosis. Gulati JS, Pedretti R, Hendren N, Kozlitina J, Saelices L, Roth LR, Grodin JL. Curr Heart Fail Rep. 2025 Feb 13;22(1):8.
2024
Detection of ATTR aggregates in the plasma of polyneuropathic patients with ATTR-V30M amyloidosis. Pedretti R, Wang L, Grodin JL, Masri A, Kelly J, Saelices L. Amyloid. 2024 Dec;31(4):350-352.
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis.
Nguyen BA, Singh V, Afrin S, Singh P, Pekala M, Ahmed Y, Pedretti R, Canepa J, Lemoff A, Kluve-Beckerman B, Wydorski P, Chhapra F, Saelices L, 2024 Mar bioRxiv
Circulating transthyretin and retinol binding protein 4 levels among middle-age V122I TTR carriers in the general population.
Hendren NS, De Lemos JA, Berry JD, Kozlitina J, Saelices L, Ji AX, Shao Z, Liu CF, Garg S, Farr MA, Drazner MH, Tang WHW, Grodin JL, 2024 Mar Amyloid 1-8
Author Correction: O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology.
Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR, 2024 Feb Nat Chem Biol
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology.
Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR, 2024 Feb Nat Chem Biol
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy.
Nguyen BA, Singh V, Afrin S, Yakubovska A, Wang L, Ahmed Y, Pedretti R, Fernandez-Ramirez MDC, Singh P, Pekala M, Cabrera Hernandez LO, Kumar S, Lemoff A, Gonzalez-Prieto R, Sawaya MR, Eisenberg DS, Benson MD, Saelices L, 2024 Jan Nat Commun 1 15 581
2023
Conformational inhibitors of protein aggregation.
Fernández Ramírez MDC, Afrin S, Saelices L, 2023 Dec Curr Opin Struct Biol 83 102700
Disease-associated patterns of acetylation stabilize tau fibril formation.
Li L, Nguyen BA, Mullapudi V, Li Y, Saelices L, Joachimiak LA, 2023 Jun Structure
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils.
Tayeb-Fligelman E, Bowler JT, Tai CE, Sawaya MR, Jiang YX, Garcia G, Griner SL, Cheng X, Salwinski L, Lutter L, Seidler PM, Lu J, Rosenberg GM, Hou K, Abskharon R, Pan H, Zee CT, Boyer DR, Li Y, Anderson DH, Murray KA, Falcon G, Cascio D, Saelices L, Damoiseaux R, Arumugaswami V, Guo F, Eisenberg DS, 2023 Apr Nat Commun 1 14 2379
O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology.
Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR, 2023 Mar bioRxiv
Disease-associated patterns of acetylation stabilize tau fibril formation.
Li L, Nguyen B, Mullapudi V, Saelices L, Joachimiak LA, 2023 Jan bioRxiv
2022
Update on Disease-Specific Biomarkers in Transthyretin Cardiac Amyloidosis.
Hood CJ, Hendren NS, Pedretti R, Roth LR, Saelices L, Grodin JL, 2022 Aug Curr Heart Fail Rep
Structural polymorphism of amyloid fibrils in cardiac ATTR amyloidosis revealed by cryo-electron microscopy
Nguyen BA, Afrin S, Singh V, Ahmed Y, Pedretti R, Fernandez-Ramirez M, Benson MD, Sawaya RM, Cao Q, Boyer D, Pope A, Wydorski PM, Chhapra F, Eisenberg DS, Saelices L 2022 bioRxiv 2022.06.21 496949
2021
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores.
Cao Q, Boyer DR, Sawaya MR, Abskharon R, Saelices L, Nguyen BA, Lu J, Murray KA, Kandeel F, Eisenberg DS, 2021 Sep Nat Struct Mol Biol 9 28 724-730
General model for estimation of indoor radon concentration dynamics.
Dvorzhak A, Mora JC, Real A, Sainz C, Fuente I, 2021 Oct Environ Sci Pollut Res Int 38 28 54085-54095
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2.
Tayeb-Fligelman E, Cheng X, Tai C, Bowler JT, Griner S, Sawaya MR, Seidler PM, Jiang YX, Lu J, Rosenberg GM, Salwinski L, Abskharon R, Zee CT, Hou K, Li Y, Boyer DR, Murray KA, Falcon G, Anderson DH, Cascio D, Saelices L, Damoiseaux R, Guo F, Eisenberg DS, 2021 Mar bioRxiv