Publications
SELECT: 2026 | 2025 – 2021 | 2020 – 2015
2025
Structural and molecular homogeneity of ATTRv-T60A amyloid fibrils across patients and organs
Fernandez-Ramirez MDC, Nguyen BA, Afrin S, Singh V, Evers B, Shelton JM, Escobar CL, Bassett P, Wang L, Pękała M, Ahmed Y, Cabrera Hernandez LO, Pedretti R, Singh P, Canepa J, Wosztyl A, Li Y, Boyer DR, Cao Q, Saelices L
Structure
Polymorphic IGLV6-57 AL amyloid fibrils and features of a shared folding pathway
Bassett PT, Nguyen BA, Singh V, Garrett PT, Moresco JJ, Eddy J, Afrin S, Pękała M, Lopez C, Evers BM, Ahmed Y, Grodin JL, Roth LR, Kaur G, Chung S, Morgan GJ, Yates JR, Saelices L
bioRxiv
A Rare Unusually Aggressive Form of Hereditary Transthyretin Amyloidosis
Zhang J, Roth LR, Wees I, Phillips L, Pedretti R, Nguyen P, Saelices L, Grodin JL
JACC: Case Reports
Mechanism of inhibition of acid-mediated transthyretin aggregation by designed peptides
Sun X, Pedretti R, Dyson HJ, Saelices L, Wright PE
Journal of Biological Chemistry
A Shared Amyloid Architecture in Cardiac Fibrils from Three Neuropathy-Associated ATTR Variants
Fernandez-Ramirez MDC, Afrin S, Nguyen BA, Singh V, Pekala M, Singh P, Ahmed Y, Pedretti R, Lemoff A, Kluve-Beckerman B, Chhapra F, Eisenberg D, Saelices L
bioRxiv
Risk for Heart Failure and Atrial Fibrillation Across the Lifespan for Carriers of the Amyloidogenic p.V142I TTR Variant
Grodin JL, Gupta A, Rison I Jr, Kozlitina J, Saelices L, Girotra S, Shah AM, Roth LR, Griffin JM, Drazner MH, Tang WHW, Maurer MS, de Lemos JA
Circulation: Genomic & Precision Medicine
Structural polymorphism of ex-vivo ALECT2 amyloid fibrils revealed by cryo-EM
Afrin S, Nguyen BA, Singh V, Singh P, Bassett P, Pekala M, Evers B, Lopez C, Ahmed Y, Li L, Kallem RR, Lemoff A, Argyropoulos C, Kluve-Beckerman B, Saelices L
bioRxiv
Structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations, revealed by cryo-EM
Nguyen BA, Fernandez-Ramirez MDC, Bassett P, Singh V, Singh P, Pękała M, Villalon L, Ahmed Y, Lemoff A, Evers B, Lopez C, Kluve-Beckerman B, Saelices L
bioRxiv
Biomarkers in Subclinical Transthyretin Cardiac Amyloidosis
Gulati JS, Pedretti R, Hendren N, Kozlitina J, Saelices L, Roth LR, Grodin JL
Current Heart Failure Reports
2024
ATTRv-V30M amyloid fibrils from heart and nerves exhibit structural homogeneity
Nguyen BA, Afrin S, Yakubovska A, Singh V, Pedretti R, Bassett P, Pekala M, Alicea JV, Kunach P, Wang L, Lemoff A, Kluve-Beckerman B, Saelices L
Structure
Detection of ATTR aggregates in the plasma of polyneuropathic patients with ATTR-V30M amyloidosis
Pedretti R, Wang L, Grodin JL, Masri A, Kelly J, Saelices L
Amyloid
Structure-Based Probe Reveals the Presence of Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients
Pedretti R, Wang L, Yakubovska A, Zhang QS, Nguyen BA, Grodin JL, Masri A, Saelices L
JACC: Basic to Translational Science
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis
Nguyen BA, Singh V, Afrin S, Singh P, Pekala M, Ahmed Y, Pedretti R, Canepa J, Lemoff A, Kluve-Beckerman B, Wydorski PM, Chhapra F, Saelices L
Communications Biology
Circulating transthyretin and retinol binding protein 4 levels among middle-age V122I TTR carriers in the general population
Hendren NS, De Lemos JA, Berry JD, Kozlitina J, Saelices L, Ji AX, Shao Z, Liu CF, Garg S, Farr MA, Drazner MH, Tang WHW, Grodin JL
Amyloid
Detection of Circulating Transthyretin Amyloid Aggregates in Plasma: A Novel Biomarker for Transthyretin Amyloidosis
Pedretti R, Wang L, Hanna M, Benson MD, Grodin JL, Tang WHW, Masri A, Saelices L
Circulation
ATTRv-V30M Type A amyloid fibrils from heart and nerves exhibit structural homogeneity
Nguyen BA, Afrin S, Yakubovska A, Singh V, Alicea JV, Kunach P, Singh P, Pekala M, Ahmed Y, Fernandez-Ramirez MDC, Hernandez LOC, Pedretti R, Bassett P, Wang L, Lemoff A, Villalon L, Kluve-Beckerman B, Saelices L
bioRxiv
Amyloid fibril polymorphism in the heart and liver of an ATTR amyloidosis patient with polyneuropathy attributed to the ATTRv-V122Δ variant
Ahmed Y, Nguyen BA, Kelly C, Afrin S, Singh V, Evers B, Shelton J, Lopez Escobar C, Singh P, Pedretti R, Wang L, Bassett P, Fernandez-Ramirez MDC, Pekala M, Lemoff A, Kluve-Beckerman B, Saelices L
bioRxiv
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology
Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR
Nature Chemical Biology
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis
Nguyen BA, Singh V, Afrin S, Singh P, Pekala M, Ahmed Y, Pedretti R, Canepa J, Lemoff A, Kluve-Beckerman B, Wydorski P, Chhapra F, Saelices L
bioRxiv
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy
Nguyen BA, Singh V, Afrin S, Yakubovska A, Wang L, Ahmed Y, Pedretti R, Fernandez-Ramirez MDC, Singh P, Pękała M, Cabrera Hernandez LO, Kumar S, Lemoff A, Gonzalez-Prieto R, Sawaya MR, Eisenberg DS, Benson MD, Saelices L
Communications
2023
Conformational inhibitors of protein aggregation
Fernández Ramírez MDC, Afrin S, Saelices L
Current Opinion in Structural Biology
Disease-associated patterns of acetylation stabilize tau fibril formation
Li L, Nguyen BA, Mullapudi V, Li Y, Saelices L, Joachimiak LA
Structure
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils
Tayeb-Fligelman E, Bowler JT, Tai CE, Sawaya MR, Jiang YX, Garcia G Jr, Griner SL, Cheng X, Salwinski L, Lutter L, Seidler PM, Lu J, Rosenberg GM, Hou K, Abskharon R, Pan H, Zee CT, Boyer DR, Li Y, Anderson DH, Murray KA, Falcon G, Cascio D, Saelices L, Damoiseaux R, Arumugaswami V, Guo F, Eisenberg DS
Nature Communications
O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology
Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR
bioRxiv
Disease-associated patterns of acetylation stabilize tau fibril formation
Li L, Nguyen BA, Mullapudi V, Saelices L, Joachimiak LA
bioRxiv
2022
Update on Disease-Specific Biomarkers in Transthyretin Cardiac Amyloidosis
Hood CJ, Hendren NS, Pedretti R, Roth LR, Saelices L, Grodin JL
Current Heart Failure Reports
2021
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Cao Q, Boyer DR, Sawaya MR, Abskharon R, Saelices L, Nguyen BA, Lu J, Murray KA, Kandeel F, Eisenberg DS
Nature Structural & Molecular Biology
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2
Tayeb-Fligelman E, Cheng X, Tai C, Bowler JT, Griner S, Sawaya MR, Seidler PM, Jiang YX, Lu J, Rosenberg GM, Salwinski L, Abskharon R, Zee CT, Hou K, Li Y, Boyer DR, Murray KA, Falcon G, Anderson DH, Cascio D, Saelices L, Damoiseaux R, Guo F, Eisenberg DS
bioRxiv